Chillicothe, located in Ross County, Ohio, is recognized as a strategic center for industrial growth and commercial development. With its strong transportation network, skilled workforce, and coordinated economic development support, the region provides a solid foundation for long-term business success.
Overview of the Business & Industrial Sector in Chillicothe & Ross County
Known for its historic significance as Ohio’s first capital and its strong civic identity, Chillicothe offers a balanced environment for businesses across manufacturing, healthcare, logistics, retail, and professional services. Positioned along U.S. Route 23 and U.S. Route 35, the city connects efficiently to major state markets and distribution routes.
From advanced manufacturing and automotive to healthcare, education, and supply chain services, Chillicothe supports a diverse business base with competitive operating costs, workforce training partnerships, and strong collaboration across chamber, city, and regional development organizations.
Key Drivers of Business & Industrial Success
Prime Location & Transportation Network
Chillicothe’s strategic positioning supports streamlined logistics, commuting, and distribution access:
- U.S. Route 23 and U.S. Route 35 provide direct multi-directional highway access
- Norfolk Southern rail service supports industrial shipping and freight
- Ross County Airport accommodates corporate, freight, and general aviation
- Approximately 45–60 minutes to Columbus and central Ohio markets
- Convenient access to I-71, I-70, and I-75 freight corridors
Workforce Development & Talent Access
The region offers strong workforce pipelines supported by educational and training institutions:
- Ohio University Chillicothe provides degree programs and workforce advancement
- Pickaway-Ross Career & Technology Center delivers technical, trade, and industry certifications
- Shawnee State University’s partnership with Adena Health can help residents continue their education in a Ross County classroom
- Local school districts integrate career readiness and skills education
- Employer partnerships support upskilling, apprenticeships, and job placement
Cost-Effective Industrial & Commercial Space
Chillicothe provides competitively priced sites and facilities for expanding or relocating businesses:
- Multiple industrial parks and development sites throughout Ross County
- Redevelopment and adaptive reuse opportunities in historic and commercial districts
- Available commercial land with utility and transportation access
- Support for companies investing in build-to-suit and expansion projects
Business-Friendly Governance
Local and regional partners work together to support business growth:
- Streamlined permitting and development coordination through city and county agencies
- Designated Opportunity Zones supporting long-term investment potential
- Close collaboration with Greater Chillicothe & Ross County Development for site selection, incentives, and expansion planning
Local Highlights Strengthening Chillicothe’s Industrial Profile
Anchor Employers & Institutions
- Kenworth Truck Company (PACCAR): Major manufacturing and regional employer
- Adena Health System: Anchor healthcare provider and workforce driver
- Chillicothe VA Medical Center: Federal healthcare and veteran services center
- Petland Headquarters: National retailer headquartered in Chillicothe
Notable Business Districts
- Historic Downtown Chillicothe: Local shops, offices, dining, and entrepreneurial activity
- Bridge Street Commercial Corridor: Retail, service, and high-traffic business development
- Western Avenue Corridor: Expanding healthcare, commercial, and professional services district
Educational and Training Assets
- Ohio University Chillicothe: Higher education, workforce development, and continuing education
- Pickaway-Ross CTC: Technical and vocational training aligned to employer needs
- Local School Career Pathway Programs: Early exposure to trades, healthcare, and business careers
Community Resources Supporting Business Growth
Chamber of Commerce Programs
The Chillicothe Ross Chamber of Commerce supports businesses at every stage:
- Business promotion through events, networking, and visibility programs
- Advocacy on local, regional, and state business issues
- Strategic partnerships to support workforce, development, and growth initiatives
- The Southern Ohio Employer Resource Network helps you retain great employees by helping employers remove the barriers between their employees and their job
Regional Incentives and Partnerships
- Greater Chillicothe & Ross County Development: Business attraction, retention, and expansion support
- Ohio Means Jobs – Ross County: Talent recruitment, training grants, and workforce services
- City and County Development Programs: Support for site readiness, redevelopment, and infrastructure upgrades
Chillicothe & Ross County: A Competitive Location for Industrial and Commercial Investment
Chillicothe offers a powerful combination of accessibility, affordability, and community partnership, making it well suited for manufacturers, healthcare providers, logistics firms, professional services, and entrepreneurs alike.
Businesses benefit from:
- Strategic Ohio location with access to major markets
- Competitive industrial and commercial space
- Workforce and training systems aligned with employer needs
- Coordinated support from Chamber, development partners, and civic leadership
With a commitment to innovation, heritage, and shared economic progress, Chillicothe continues to strengthen its role as a regional leader in business and industrial development.